Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Overexpression of an Aurora-C kinase-deficient mutant disrupts the Aurora-B/INCENP complex and induces polyploidy.

Journal of biomedical science - 1 Jan 2005

Chen Hua-Ling, Tang Chieh-Ju C, Chen Chiung-Ya, Tang Tang K

Abstract excerpt

Aurora kinases are emerging as key regulators of centrosome function, chromosome segregation and cytokinesis. We previously isolated Aurora-C (Aie1), a third type of Aurora kinase, in a screen for kinases expressed in mouse sperm and eggs. Currently, we know very little about the precise localiza...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aurora Kinase B
Share to Aurora Kinases
Share to Centromere

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Centrosome

Share to Cytokinesis

Share to In Situ Nick-End Labeling

Share to Spindle Apparatus

Share to Tetracycline

Source

Identifiers

PMID: 15917996
DOI: 10.1007/s11373-005-0980-0

Genes

INCENP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-15917996-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Overexpression of an Aurora-C kinase-deficient mutant disrupts the Aurora-B/INCENP complex and induces polyploidy.PMID 15917996Read ↗

Aurora-C kinase deficiency causes cytokinesis failure in meiosis I and production of large polyploid oocytes in mice.Semantic proximity Read ↗

Genetic disruption of aurora B uncovers an essential role for aurora C during early mammalian developmentSemantic proximity Read ↗

Aurora C is directly associated with Survivin and required for cytokinesis.Semantic proximity Read ↗

Aurora Kinases and Potential Medical Applications of Aurora Kinase Inhibitors: A ReviewSemantic proximity Read ↗

Gradient of increasing Aurora B kinase activity is required for cells to execute mitosis.Semantic proximity Read ↗

Cloning and characterization of a novel human Aurora C splicing variant.Semantic proximity Read ↗

The Aurora kinases: role in cell transformation and tumorigenesis.Semantic proximity Read ↗

Aurora Kinases: New Targets for Cancer TherapySemantic proximity Read ↗

Exploring the functional interactions between Aurora B, INCENP, and survivin in mitosis.Semantic proximity Read ↗

Roles of Aurora kinases in mitosis and tumorigenesis.Semantic proximity Read ↗

Aberrantly expressed AURKC enhances the transformation and tumourigenicity of epithelial cellsSemantic proximity Read ↗

Aurora-A kinase is essential for bipolar spindle formation and early development.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.