The winged-helix transcription factor HNF-3 beta is required for notochord development in the mouse embryo.

doi:10.1016/0092-8674(94)90523-1

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Article

The winged-helix transcription factor HNF-3 beta is required for notochord development in the mouse embryo.

Cell - 26 Aug 1994

Weinstein D C, Ruiz i Altaba A, Chen W S, Hoodless P, Prezioso V R, Jessell T M, Darnell J E

Abstract excerpt

HNF-3 beta, a transcription factor of the winged-helix family, is expressed in embryonic and adult endoderm and also in midline cells of the node, notochord, and floor plate in mouse embryos. To define the function of HNF-3 beta, a targeted mutation in the HNF-3 beta locus was generated by homologous recombination in embryonic stem cells. Mice lacking HNF-3 beta die by embryonic day (E) 10-11. Mutant embryos...

Topics

Animals
Base Sequence
Cell Differentiation
Central Nervous System
Chimera
DNA-Binding Proteins
Female
Gastrula
Hepatocyte Nuclear Factor 3-beta
Male
Mesoderm

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mice

Mice, Inbred C57BL

Molecular Sequence Data

Mutation

Notochord

Nuclear Proteins

Phenotype

Source

Open in PubMed

Identifiers

PMID: 8069910
DOI: 10.1016/0092-8674(94)90523-1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-8069910-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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