Article

Sentinel Interaction Mapping (SIM) – A generic approach for the functional analysis of human disease gene variants using yeast

2020-02-14

Abstract excerpt

Advances in sequencing technology have led to an explosion in the number of known genetic variants of human genes. A major challenge is to now determine which of these variants contribute to diseases as a result of their effect on gene function. Here we describe a generic approach using the yeast Saccharomyces cerevisiae to quickly develop gene-specific in vivo assays that can be used to quantify the level of fu...

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Literature Corpus work: 7c9a08dd-563a-57ed-84a1-52cd36f0bec5
DOI: 10.1101/2020.02.14.949198

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