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Article

Sentinel interaction mapping - a generic approach for the functional analysis of human disease gene variants using yeast.

Disease models & mechanisms - 8 Jul 2020

Young Barry P, Post Kathryn L, Chao Jesse T, Meili Fabian, Haas Kurt, Loewen Christopher

Abstract excerpt

Advances in sequencing technology have led to an explosion in the number of known genetic variants of human genes. A major challenge is to now determine which of these variants contribute to diseases as a result of their effect on gene function. Here, we describe a generic approach using the yeast Saccharomyces cerevisiae to quickly develop gene-specific in vivo assays that can be used to quantify the level of...

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Identifiers

PMID: 32471850
DOI: 10.1242/dmm.044560
PMCID: PMC7358137

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