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Article

The interaction between the Spt6-tSH2 domain and Rpb1 affects multiple functions of RNA Polymerase II.

Nucleic acids research - 25 Jan 2022

Connell Zaily, Parnell Timothy J, McCullough Laura L, Hill Christopher P, Formosa Tim

Abstract excerpt

The conserved transcription elongation factor Spt6 makes several contacts with the RNA Polymerase II (RNAPII) complex, including a high-affinity interaction between the Spt6 tandem SH2 domain (Spt6-tSH2) and phosphorylated residues of the Rpb1 subunit in the linker between the catalytic core and the C-terminal domain (CTD) heptad repeats. This interaction contributes to generic localization of Spt6, but we show...

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PMID: 34967414
DOI: 10.1093/nar/gkab1262
PMCID: PMC8789061

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