Article

INTS12 Bridges Integrator and NELF to Prevent the Release of Non-processive RNA Polymerase II Complexes

2026-01-17

Abstract excerpt

Promoter-proximal RNA Polymerase II (RNAPII) pausing and the processivity are controlled by distinct modules of the Integrator complex, which together fine-tune transcription and protect against the accumulation of defective RNAPII complexes. Compromised activity of individual Integrator modules has been linked to human disease including cancer and developmental disorders, caused by defective transcription of prot...

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Literature Corpus work: 893c3a92-d9c2-50d7-b4da-42ef80e1bf6e
DOI: 10.64898/2026.01.16.699819

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