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Article

Dual roles for Spt5 in pre-mRNA processing and transcription elongation revealed by identification of Spt5-associated proteins.

Molecular and cellular biology - 1 Feb 2003

Lindstrom D L, Squazzo S L, Muster N, Burckin T A, Wachter K C, Emigh C A, McCleery J A, Yates J R, Hartzog G A

Abstract excerpt

During transcription elongation, eukaryotic RNA polymerase II (Pol II) must contend with the barrier presented by nucleosomes. The conserved Spt4-Spt5 complex has been proposed to regulate elongation through nucleosomes by Pol II. To help define the mechanism of Spt5 function, we have characterized proteins that coimmunopurify with Spt5. Among these are the general elongation factors TFIIF and TFIIS as well as...

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Identifiers

PMID: 12556496
DOI: 10.1128/MCB.23.4.1368-1378.2003
PMCID: PMC141151

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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