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Article

Tripartite phosphorylation of SPT5 by CDK9 times pause release and tunes elongation rate of RNA polymerase II.

Molecular cell - 1 May 2025

Sun Rui, Fisher Robert P

Abstract excerpt

The RNA polymerase II (RNAPII) transcription cycle is regulated throughout its duration by protein phosphorylation. Previously, two regions phosphorylated by cyclin-dependent kinase 9 (CDK9) in elongation factor SPT5-the linker between Kyrpides-Ouzounis-Woese (KOW) x-4 and 5 domains and carboxy-terminal repeat (CTR) 1-were implicated in promoter-proximal pausing and termination, respectively. Here, we show that...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 40250441
DOI: 10.1016/j.molcel.2025.03.021
PMCID: PMC12048218

Genes

CDK9

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

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