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Article

Spt5's central KOW domains and the Pol II stalk collaborate to regulate chromatin and 3'-end processing in Saccharomyces cerevisiae.

G3 (Bethesda, Md.) - 6 Jul 2026

Morton Zachary A, Doody Michael J, Naik Nayeli, Paniagua Nancy, Delahunty Claire, Yates John R, Bustamante Carlos, Hartzog Grant A

Abstract excerpt

Spt5 is a universally conserved multidomain transcription elongation factor that acts as a component of all Pol II elongation complexes (ECs). Structural studies indicate that several of Spt5's central KOW domains lie adjacent to the Pol II stalk, composed of subunits Rpb4 and Rpb7. However, the in vivo functions of Spt5's central KOW domains are unknown. Here, we show that Spt5 and Rpb4/7 jointly modulate 3'-end...

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Identifiers

PMID: 42109095
DOI: 10.1093/g3journal/jkag123
PMCID: PMC13334181

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