Article
Spt5 Plays Vital Roles in the Control of Sense and Antisense Transcription Elongation.
Molecular cell - 6 Apr 2017
Shetty Ameet, Kallgren Scott P, Demel Carina, Maier Kerstin C, Spatt Dan, Alver Burak H, Cramer Patrick, Park Peter J, Winston Fred
Abstract excerpt
Spt5 is an essential and conserved factor that functions in transcription and co-transcriptional processes. However, many aspects of the requirement for Spt5 in transcription are poorly understood. We have analyzed the consequences of Spt5 depletion in Schizosaccharomyces pombe using four genome-wide approaches. Our results demonstrate that Spt5 is crucial for a normal rate of RNA synthesis and distribution of...
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