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Article

HSF1 is involved in suppressing A1 phenotype conversion of astrocytes following spinal cord injury in rats.

Journal of neuroinflammation - 16 Sept 2021

Li Lilan, Li Yu, He Bingqiang, Li Hui, Ji Huiyuan, Wang Yingjie, Zhu Zhenjie, Hu Yuming, Zhou Yue, Yang Ting, Sun Chunshuai, Yuan Ying, Wang Yongjun

Abstract excerpt

BACKGROUND: Two activation states of reactive astrocytes termed A1 and A2 subtypes emerge at the lesion sites following spinal cord injury (SCI). A1 astrocytes are known to be neurotoxic that participate in neuropathogenesis, whereas A2 astrocytes have been assigned the neuroprotective activity. Heat shock transcription factor 1 (HSF1) plays roles in protecting cells from stress-induced apoptosis and in...

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Source

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Identifiers

PMID: 34530848
DOI: 10.1186/s12974-021-02271-3
PMCID: PMC8444373

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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