Article

Blocking A1 astrocyte conversion with semaglutide attenuates blood-brain barrier disruption in mice after middle cerebral artery occlusion

2021-04-22

Abstract excerpt

<title>Abstract</title> <p>Background Astrocytes play an essential role in the modulation of blood-brain barrier function. Neurological diseases induce astrocytes to transform into a neurotoxic A1 phenotype, thus exacerbating brain injury. However, the effect of A1 astrocyte on the function of BBB after stroke is unknown. <h4>Method:</h4> Adult male ICR mice (n = 78) were subjected to 90-minute transient middle...

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Literature Corpus work: 83e7447e-e715-5107-8cb7-bfb3c2660ca9
DOI: 10.21203/rs.3.rs-434590/v1

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