Article
Phenotypic shift of astrocytes from A1 to A2 induced by fasudil improves demyelination recovery in cuprizone-treated mice.
Metabolic brain disease - 7 Sept 2026
Xu Kun, Yang Ting, Dong Hao-Ran, Yin Tai-Song, Yin Jun-Jun, Song Li-Juan, Xiao Bao-Guo, Yin Jin-Zhu, Liu Chun-Sheng, Ma Cun-Gen, Li Xin-Yi, Ding Zhi-Bin
Abstract excerpt
Multiple sclerosis (MS) is a chronic autoimmune disorder of the central nervous system (CNS), characterized by neuroinflammation, demyelination, and subsequent axonal degeneration. Astrocytes (ASTs) play a dual role in MS pathogenesis, adopting either neurotoxic A1 or neuroprotective A2 phenotypes, which respectively inhibit or promote myelin repair. Fasudil (FSD), a Rho kinase inhibitor, has demonstrated...
Read the complete abstract on PubMedTopics
- Animals
- Cuprizone
- 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine
- Mice
- Demyelinating Diseases