Article
Rho Kinase Inhibitor Y27632 Improves Recovery After Spinal Cord Injury by Shifting Astrocyte Phenotype and Morphology via the ROCK/NF-κB/C3 Pathway.
Neurochemical research - 1 Dec 2022
Zhang Yongyuan, Wang Xiaohui, Jiang Chao, Chen Zhe, Ni Shuangyang, Fan Hong, Wang Zhiyuan, Tian Fang, An Jing, Yang Hao, Hao Dingjun
Abstract excerpt
Spinal cord injury (SCI) usually results in loss or reduction in motor and sensory functions. Despite extensive research, no available therapy can restore the lost functions after SCI. Reactive astrocytes play a pivotal role in SCI. Rho kinase inhibitors have also been shown to promote functional recovery of SCI. However, the role of Rho kinase inhibitors in reactive astrocytic phenotype switch within SCI remains...
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