Placental Mesenchymal Stem Cells Promote the Polarization of Astrocytes Towards the A2 Phenotype by Modulating the TGF-β1 Signaling Pathway in Cerebral Ischemia-Reperfusion Rats.

doi:10.3390/biom16081103

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Article

Placental Mesenchymal Stem Cells Promote the Polarization of Astrocytes Towards the A2 Phenotype by Modulating the TGF-β1 Signaling Pathway in Cerebral Ischemia-Reperfusion Rats.

Biomolecules - 28 Jul 2026

Liu Ningmei, Fu Yanyan, Wu Taojuan, Chen Dongmei, Liu Ting, Ma Haibin, Cao Chuanshang, Ma Binwu, Niu Jianguo, Liang Xueyun

Abstract excerpt

Astrocytic function imbalance is a key factor affecting cerebral ischemia rehabilitation. Mesenchymal stem cells have therapeutic potential for cerebral ischemia, but their mechanisms remain unclear. This study explored how placental mesenchymal stem cells pro-mote astrocytes towards the A2 phenotype, which benefits the repair of cerebral ischemia injury. We established the animal model of middle cerebral artery...

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PMID: 42650771
DOI: 10.3390/biom16081103
PMCID: PMC13510269

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