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Article

Osteopontin regulates proliferation, migration, and survival of astrocytes depending on their activation phenotype.

Journal of neuroscience research - 1 Nov 2021

Vay Sabine Ulrike, Olschewski Daniel Navin, Petereit Helena, Lange Felix, Nazarzadeh Nilufar, Gross Elena, Rabenstein Monika, Blaschke Stefan Johannes, Fink Gereon Rudolf, Schroeter Michael, Rueger Maria Adele

Abstract excerpt

The glycoprotein osteopontin is highly upregulated in central nervous system (CNS) disorders such as ischemic stroke. Osteopontin regulates cell growth, cell adhesion, homeostasis, migration, and survival of various cell types. Accordingly, osteopontin is considered an essential regulator of regeneration and repair in the ischemic milieu. Astrocytes are the most abundant cells in the CNS and play significant...

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Identifiers

PMID: 34510519
DOI: 10.1002/jnr.24954

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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