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Article

Ablation of USP21 in skeletal muscle promotes oxidative fibre phenotype, inhibiting obesity and type 2 diabetes.

Journal of cachexia, sarcopenia and muscle - 1 Dec 2021

Kim Ayoung, Koo Ja Hyun, Jin Xing, Kim Wondong, Park Shi-Young, Park Sunghyouk, Rhee Eugene P, Choi Cheol Soo, Kim Sang Geon

Abstract excerpt

BACKGROUND: Skeletal muscle as a metabolic consumer determines systemic energy homeostasis by regulating myofibre type conversion and muscle mass control. Perturbation of the skeletal muscle metabolism elevates the risk of a variety of diseases including metabolic disorders. However, the regulatory pathways and molecules are not completely understood. The discovery of relevant responsible molecules and the...

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Identifiers

PMID: 34523817
DOI: 10.1002/jcsm.12777
PMCID: PMC8718070

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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