Article

Proteome-wide systems genetics identifies UFMylation as a regulator of skeletal muscle function

2022-08-22

Abstract excerpt

Improving muscle function has great potential to improve the quality of life. To identify novel regulators of skeletal muscle metabolism and function, we performed a proteomic analysis of gastrocnemius muscle from 73 genetically distinct inbred mouse strains, and integrated the data with genomics and >300 molecular/phenotypic traits via quantitative trait loci mapping and correlation network analysis. These data i...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: fa4016a7-bf16-500c-9405-8c273eff23d5
DOI: 10.1101/2022.08.22.504871

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Proteome-wide systems genetics identifies UFMylation as a regulator of skeletal muscle functionDOI 10.1101/2022.08.22.504871Read

Proteome-wide systems genetics identifies UFMylation as a regulator of skeletal muscle function.Semantic proximity Read

Elucidating the molecular landscape of centronuclear myopathies in mouse models: an integrative multi-omics and network analysisSemantic proximity Read

Molecular Transducers of Human Skeletal Muscle Remodeling under Different Loading StatesSemantic proximity Read

Proteomic profiling uncovers sexual dimorphism in the muscle response to wheel running exercise in the FLExDUX4 murine model of facioscapulohumeral muscular dystrophySemantic proximity Read

Profiling of the muscle-specific dystroglycan interactome reveals the role of Hippo signaling in muscular dystrophy and age-dependent muscle atrophy.Semantic proximity Read

A Joint Promoterome-Proteome Atlas Highlights the Molecular Diversity of Human Skeletal MusclesSemantic proximity Read

Genome-wide associations reveal human-mouse genetic convergence and modifiers of myogenesis, <i>CPNE1</i> and <i>STC2</i>Semantic proximity Read

A human skeletal muscle interactome centered on proteins involved in muscular dystrophies: LGMD interactomeSemantic proximity Read

Systematic Analysis of UFMylation Family Genes in Tissues of Mice with Metabolic Dysfunction-Associated Steatotic Liver DiseaseSemantic proximity Read

Multi-level omics analysis in a murine model of dystrophin loss and therapeutic restoration.Semantic proximity Read

Rbfox Splicing Factors Maintain Skeletal Muscle Mass by Regulating Calpain3 and ProteostasisSemantic proximity Read

NRF1/NFE2L1 orchestrates spatiotemporal regulation of protein degradation network in skeletal muscleSemantic proximity Read