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Article

Effect of inactivation of the USP19 deubiquitinase gene in mice on important phenotypes of aging.

The journals of gerontology. Series A, Biological sciences and medical sciences - 1 Jul 2026

Sheng Kai, Coyne Erin S, Bédard Nathalie, Lu Emilie, Goltzman David, Haglund Lisbet, Wing Simon S

Abstract excerpt

Aging is associated with many chronic conditions that increase morbidity and mortality. These include obesity, diabetes, sarcopenia, osteoporosis, and neurodegeneration. The deubiquitinase USP19 is involved in many of these disorders suggesting that it may modulate common mechanism(s) that impact the aging process. Inactivation of USP19 is protective against muscle atrophy, obesity, and diabetes in young adult...

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Source

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Identifiers

PMID: 42225593
DOI: 10.1093/gerona/glag138
PMCID: PMC13341015

Genes

USP19

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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Effect of inactivation of the USP19 deubiquitinase gene in mice on important phenotypes of aging.PMID 42225593Read ↗

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