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Article

The ubiquitin proteasome system in atrophying skeletal muscle: roles and regulation

11 Aug 2016

Abstract excerpt

Muscle atrophy complicates many diseases as well as aging, and its presence predicts both decreased quality of life and survival. Much work has been conducted to define the molecular mechanisms involved in maintaining protein homeostasis in muscle. To date, the ubiquitin proteasome system (UPS) has been shown to play an important role in mediating muscle wasting. In this review, we have collated the enzymes in...

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PMID: 27510905
DOI: 10.1152/ajpcell.00125.2016

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