Article

Deubiquitinase USP1 enhances CCAAT/enhancer-binding protein beta (C/EBPβ) stability and accelerates adipogenesis and lipid accumulation

2023-05-24

Abstract excerpt

<title>Abstract</title> <p>Dysregulation of the ubiquitin-proteasome system has been implicated in the pathogenesis of several metabolic disorders, including obesity, diabetes, and non-alcoholic fatty liver disease; however, the mechanisms controlling pathogenic metabolic disorders remain unclear. Transcription factor CCAAT/enhancer binding protein beta (C/EBPβ) regulates adipogenic genes. The study showed that t...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 170c23e5-739c-54cb-b63c-55d3b12a73ba
DOI: 10.21203/rs.3.rs-2835524/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Deubiquitinase USP1 enhances CCAAT/enhancer-binding protein beta (C/EBPβ) stability and accelerates adipogenesis and lipid accumulationDOI 10.21203/rs.3.rs-2835524/v1Read

USP11 promotes lipogenesis and tumorigenesis by regulating SREBF1 stability in hepatocellular carcinomaSemantic proximity Read

Ablation of Deubiquitinase USP15 Ameliorates Non-Alcoholic Fatty Liver Disease and Non-Alcoholic SteatohepatitisSemantic proximity Read

Ablation of USP21 in skeletal muscle promotes oxidative fibre phenotype, inhibiting obesity and type 2 diabetes.Semantic proximity Read

Transcriptional Regulation of Adipocyte Differentiation: A Central Role for CCAAT/Enhancer-binding Protein (C/EBP) βSemantic proximity Read

USP1 deubiquitinates protein kinase Akt to inhibit PI3K-Akt-FoxO signalingSemantic proximity Read

The deubiquitinating enzyme USP1 modulates ERα and modulates breast cancer progressionSemantic proximity Read

Proteasome dysfunction disrupts adipogenesis and induces inflammation via ATF3Semantic proximity Read

The Mediator subunit MED20 organizes the early adipogenic complex to promote development of adipose tissues and diet-induced obesity.Semantic proximity Read

Deubiquitinase USP1 influences the dedifferentiation of mouse pancreatic β-cellsSemantic proximity Read

Investigating the potential role of USP18 in atherosclerosis by regulating cholesterol efflux based on bioinformatics analysisSemantic proximity Read

Loss of Deubiquitinase USP1 Blocks Pancreatic β-Cell Apoptosis by Inhibiting DNA Damage ResponseSemantic proximity Read

USP19 potentiates autophagic cell death via inhibiting mTOR pathway through deubiquitinating NEK9 in pancreatic cancerSemantic proximity Read