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Article

Proteome-wide systems genetics identifies UFMylation as a regulator of skeletal muscle function.

eLife - 6 Dec 2022

Molendijk Jeffrey, Blazev Ronnie, Mills Richard J, Ng Yaan-Kit, Watt Kevin I, Chau Daryn, Gregorevic Paul, Crouch Peter J, Hilton James B W, Lisowski Leszek, Zhang Peixiang, Reue Karen, Lusis Aldons J, Hudson James E, James David E, Seldin Marcus M, Parker Benjamin L

Abstract excerpt

Improving muscle function has great potential to improve the quality of life. To identify novel regulators of skeletal muscle metabolism and function, we performed a proteomic analysis of gastrocnemius muscle from 73 genetically distinct inbred mouse strains, and integrated the data with previously acquired genomics and >300 molecular/phenotypic traits via quantitative trait loci mapping and correlation network...

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Identifiers

PMID: 36472367
DOI: 10.7554/eLife.82951
PMCID: PMC9833826

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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