Article

The E3 ligase HECTD1 controls skeletal muscle sarcomere and mitochondrial integrity

2026-03-08

Abstract excerpt

<title>Abstract</title> <p> Sarcomeres are the fundamental functional units of skeletal muscle, essential for both force generation and metabolic homeostasis. While sarcomere degradation has been extensively studied, the mechanisms that preserve its integrity remain poorly defined. Here, we identify HECTD1 as an E3 ubiquitin ligase required for sarcomere maintenance and mitochondrial integrity. We show that HECT...

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Literature Corpus work: 9e0a8002-4853-5c58-a923-c457d34264ea
DOI: 10.21203/rs.3.rs-8663318/v1

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