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Article

Subclonal Genomic Architectures of Primary and Metastatic Colorectal Cancer Based on Intratumoral Genetic Heterogeneity.

Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Oct 2015

Kim Tae-Min, Jung Seung-Hyun, An Chang Hyeok, Lee Sung Hak, Baek In-Pyo, Kim Min Sung, Park Sung-Won, Rhee Je-Keun, Lee Sug-Hyung, Chung Yeun-Jun

Abstract excerpt

PURPOSE: The intratumoral heterogeneity (ITH) and the evolution of genomic architectures associated with the development of distant metastases are not well understood in colorectal cancers. EXPERIMENTAL DESIGN: We performed multiregion biopsies of primary and liver metastatic regions from five colorectal cancers with whole-exome sequencing and copy number profiling. RESULTS: In addition to a substantial level of...

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PMID: 25979483
DOI: 10.1158/1078-0432.CCR-14-2413

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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