Article
Hotspot mutation panel testing reveals clonal evolution in a study of 265 paired primary and metastatic tumors.
Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Jun 2015
Goswami Rashmi S, Patel Keyur P, Singh Rajesh R, Meric-Bernstam Funda, Kopetz E Scott, Subbiah Vivek, Alvarez Ricardo H, Davies Michael A, Jabbar Kausar J, Roy-Chowdhuri Sinchita, Lazar Alexander J, Medeiros L Jeffrey, Broaddus Russell R, Luthra Rajyalakshmi, Routbort Mark J
Abstract excerpt
PURPOSE: We used a clinical next-generation sequencing (NGS) hotspot mutation panel to investigate clonal evolution in paired primary and metastatic tumors. EXPERIMENTAL DESIGN: A total of 265 primary and metastatic tumor pairs were sequenced using a 46-gene cancer mutation panel capable of detecting one or more single-nucleotide variants as well as small insertions/deletions. Mutations were tabulated together...
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