Article
Molecular characteristics of advanced colorectal cancer and multi-hit PIK3CA mutations.
The oncologist - 6 Dec 2024
Yasin Faiza, Sokol Ethan, Vasan Neil, Pavlick Dean C, Huang Richard S P, Pelletier Maureen, Levy Mia Alyce, Pusztai Lajos, Lacy Jill, Zhang Janie Yue, Ross Jeffrey S, Cecchini Michael
Abstract excerpt
INTRODUCTION: Approximately 20% of patients living with colorectal cancer (CRC) have activating mutations in their tumors in the PIK3CA oncogene. Two or more activating mutations (multi-hit) for the PIK3CA allele increase PI3K⍺ signaling compared to single-point mutations, resulting in exceptional response to PI3K⍺ inhibition. We aimed to identify the prevalence of PIK3CA multi-hit mutations in metastatic CRC to...
Topics
- Humans
- Class I Phosphatidylinositol 3-Kinases
- Colorectal Neoplasms
- Male
- Female
- Middle Aged
- Mutation
- Aged
- Adult
- Aged, 80 and over
- Microsatellite Instability