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Article

Comprehensive characterization of clonality of driver genes revealing their clinical relevance in colorectal cancer.

Journal of translational medicine - 12 Aug 2022

Shi Jian, Wang Li, Yin Xiangzhe, Wang Lixia, Bo Lin, Liu Kailai, Feng Ke, Lin Shihua, Xu Yanjun, Ning Shangwei, Zhao Hongying

Abstract excerpt

BACKGROUND: Genomic studies of colorectal cancer have revealed the complex genomic heterogeneity of the tumor. The acquisition and selection of genomic alterations may be critical to understanding the initiation and progression of this disease. METHODS: In this study, we have systematically characterized the clonal architecture of 97 driver genes in 536 colorectal cancer patients from TCGA. RESULTS: A high...

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Identifiers

PMID: 35962343
DOI: 10.1186/s12967-022-03529-x
PMCID: PMC9373375

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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