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Article

Clonal origins and parallel evolution of regionally synchronous colorectal adenoma and carcinoma.

Oncotarget - 29 Sept 2015

Kim Tae-Min, An Chang Hyeok, Rhee Je-Keun, Jung Seung-Hyun, Lee Sung Hak, Baek In-Pyo, Kim Min Sung, Lee Sug Hyung, Chung Yeun-Jun

Abstract excerpt

Although the colorectal adenoma-to-carcinoma sequence represents a classical cancer progression model, the evolution of the mutational landscape underlying this model is not fully understood. In this study, we analyzed eight synchronous pairs of colorectal high-grade adenomas and carcinomas, four...

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Identifiers

PMID: 26336987
DOI: 10.18632/oncotarget.4834
PMCID: PMC4695021

Genes

APC
KRAS
ERBB2
TGFBR2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-26336987-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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