Mutational Heterogeneity in APC and KRAS Arises at the Crypt Level and Leads to Polyclonality in Early Colorectal Tumorigenesis.

doi:10.1158/1078-0432.CCR-17-0821

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Article

Mutational Heterogeneity in APC and KRAS Arises at the Crypt Level and Leads to Polyclonality in Early Colorectal Tumorigenesis.

Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Oct 2017

Gausachs Mireia, Borras Ester, Chang Kyle, Gonzalez Sara, Azuara Daniel, Delgado Amador Axel, Lopez-Doriga Adriana, San Lucas F Anthony, Sanjuan Xavier, Paules Maria J, Taggart Melissa W, Davies Gareth E, Ehli Erik A, Fowler Jerry, Moreno Victor, Pineda Marta, You Y Nancy, Lynch Patrick M, Lazaro Conxi, Navin Nicholas E, Scheet Paul A, Hawk Ernest T, Capella Gabriel, Vilar Eduardo

Abstract excerpt

Purpose: The majority of genomic alterations causing intratumoral heterogeneity (ITH) in colorectal cancer are thought to arise during early stages of carcinogenesis as a burst but only after truncal mutations in APC have expanded a single founder clone. We have investigated if the initial source of ITH is consequent to multiple independent lineages derived from different crypts harboring distinct truncal APC and...

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PMID: 28645942
DOI: 10.1158/1078-0432.CCR-17-0821
PMCID: PMC5626604

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APC
KRAS

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