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Characterizing multi-PIK3CA mutations across cancer types: Toward precision oncology.

Cancer medicine - 1 Jul 2024

Nakamura Kohei, Ishikawa Marin, Kawano Ryutaro, Aimono Eriko, Mizuno Takaaki, Nohara Sachio, Tanishima Shigeki, Hayashi Hideyuki, Nishihara Hiroshi

Abstract excerpt

BACKGROUND: PIK3CA mutations are implicated in various cancers, but the implications of multiple concurrent mutations and their orientations within the gene have not been fully explored. METHODS: In this study, we analyzed multi-PIK3CA mutations across a diverse pan-cancer cohort comprising 3564 tumors. RESULTS: Multi-PIK3CA mutations were present in 10.3% of all PIK3CA-mutant tumors, predominantly occurring in...

Topics

Humans
Class I Phosphatidylinositol 3-Kinases
Mutation
Neoplasms
Precision Medicine
Biomarkers, Tumor
Female

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 39054873
DOI: 10.1002/cam4.70052
PMCID: PMC11272953

Genes

PIK3CA
C2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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