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Multiclonal colorectal cancers with divergent histomorphological features and RAS mutations: one cancer or separate cancers?

Human pathology - 1 Apr 2020

Lin Ming-Tseh, Zheng Gang, Tseng Li-Hui, Zhang Peng, Ling Hua, Azad Nilo, Gocke Christopher D, Montgomery Elizabeth, Eshleman James R

Abstract excerpt

Detection of coexisting mutations within the same signal transduction pathway, which are expected to be mutually exclusive, raises a concern of laboratory errors. We have previously confirmed the presence of different RAS (KRAS and NRAS) mutations in the adenoma and/or adenocarcinoma subpopulations of colorectal cancers (CRCs). In this study, multiregional analyses by next-generation sequencing were conducted to...

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PMID: 32171651
DOI: 10.1016/j.humpath.2020.03.002

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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