Article
Systematic pan-cancer analysis of somatic allele frequency.
Scientific reports - 16 May 2018
Spurr Liam, Li Muzi, Alomran Nawaf, Zhang Qianqian, Restrepo Paula, Movassagh Mercedeh, Trenkov Chris, Tunnessen Nerissa, Apanasovich Tatiyana, Crandall Keith A, Edwards Nathan, Horvath Anelia
Abstract excerpt
Imbalanced expression of somatic alleles in cancer can suggest functional and selective features, and can therefore indicate possible driving potential of the underlying genetic variants. To explore the correlation between allele frequency of somatic variants and total gene expression of their harboring gene, we used the unique data set of matched tumor and normal RNA and DNA sequencing data of 5523 distinct...
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