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Article

Region-specific H3K9me3 gain in aged somatic tissues in Caenorhabditis elegans.

PLoS genetics - 1 Sept 2021

Li Cheng-Lin, Pu Mintie, Wang Wenke, Chaturbedi Amaresh, Emerson Felicity J, Lee Siu Sylvia

Abstract excerpt

Epigenetic alterations occur as organisms age, and lead to chromatin deterioration, loss of transcriptional silencing and genomic instability. Dysregulation of the epigenome has been associated with increased susceptibility to age-related disorders. In this study, we aimed to characterize the age-dependent changes of the epigenome and, in turn, to understand epigenetic processes that drive aging phenotypes. We...

Topics

Aging
Animals
Caenorhabditis elegans
Caenorhabditis elegans Proteins
Histones
Mutation
RNA
Receptors, Notch
Retroelements
Stress, Physiological

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 34506495
DOI: 10.1371/journal.pgen.1009432
PMCID: PMC8457455

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