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Article

Two SET domain containing genes link epigenetic changes and aging in Caenorhabditis elegans.

Aging cell - 1 Apr 2012

Ni Zhuoyu, Ebata Atsushi, Alipanahiramandi Elham, Lee Siu Sylvia

Abstract excerpt

Changes in epigenetic status and chromatin structure have been shown to associate with aging in many organisms. Here, we report an RNAi screen of putative histone methyltransferases and demethylases in wild-type Caenorhabditis elegans using reproduction inhibitor. We identified six genes that when inactivated by RNAi, consistently extend lifespan. Five of these genes do not require germline proliferation to...

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Identifiers

PMID: 22212395
DOI: 10.1111/j.1474-9726.2011.00785.x
PMCID: PMC3306474

Genes

SET

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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