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Article

Chromatin-modifying genetic interventions suppress age-associated transposable element activation and extend life span in Drosophila.

Proceedings of the National Academy of Sciences of the United States of America - 4 Oct 2016

Wood Jason G, Jones Brian C, Jiang Nan, Chang Chengyi, Hosier Suzanne, Wickremesinghe Priyan, Garcia Meyrolin, Hartnett Davis A, Burhenn Lucas, Neretti Nicola, Helfand Stephen L

Abstract excerpt

Transposable elements (TEs) are mobile genetic elements, highly enriched in heterochromatin, that constitute a large percentage of the DNA content of eukaryotic genomes. Aging in Drosophila melanogaster is characterized by loss of repressive heterochromatin structure and loss of silencing of reporter genes in constitutive heterochromatin regions. Using next-generation sequencing, we found that transcripts of many...

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PMID: 27621458
DOI: 10.1073/pnas.1604621113
PMCID: PMC5056045

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