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Article

High-Throughput Gene and Protein Analysis Revealed the Response of Disc Cells to Vitamin D, Depending on the VDR FokI Variants.

International journal of molecular sciences - 4 Sept 2021

Colombini Alessandra, De Luca Paola, Cangelosi Davide, Perucca Orfei Carlotta, Ragni Enrico, Viganò Marco, Malacarne Michela, Castagnetta Mauro, Brayda-Bruno Marco, Coviello Domenico, de Girolamo Laura

Abstract excerpt

Vitamin D showed a protective effect on intervertebral disc degeneration (IDD) although conflicting evidence is reported. An explanation could be due to the presence of the FokI functional variant in the vitamin D receptor (VDR), observed as associated with spine pathologies. The present study was aimed at investigating-through high-throughput gene and protein analysis-the response of human disc cells to vitamin...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 34502510
DOI: 10.3390/ijms22179603
PMCID: PMC8431769

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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