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Analysis of FokI polymorphism of vitamin D receptor gene in intervertebral disc degeneration.

Genetic testing and molecular biomarkers - 1 Sept 2014

Vieira Luiz Angelo, De Marchi Patricia Leme, dos Santos Aline Amaro, Christofolini Denise Maria, Barbosa Caio Parente, Fonseca Fernando Luiz Affonso, Bianco Bianca, Rodrigues Luciano Miller R

Abstract excerpt

AIM: We have hypothesized a possible relationship between disc degeneration (DD) and VDR FokI/T2C polymorphism. METHODS: A case-control study was performed comprising 121 Brazilian patients with confirmed DD by nuclear magnetic resonance and a control group consisting of 131 healthy patients without a history of disc cysts of the lumbar spine. Detection of VDR FokI/T2C polymorphism was performed using restriction...

Topics

Adult
Alleles
Brazil
Deoxyribonucleases, Type II Site-Specific
Female
Gene Frequency
Humans
Intervertebral Disc Degeneration
Magnetic Resonance Imaging
Male

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Middle Aged

Polymerase Chain Reaction

Prospective Studies

Radiography

Receptors, Calcitriol

Source

Open in PubMed Open full text

Identifiers

PMID: 25006683
DOI: 10.1089/gtmb.2014.0030
PMCID: PMC4150369

Genes

VDR

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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