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Article

Investigating the association between FOK1 polymorphism in the vitamin D receptor (VDR) gene and type 2 diabetes prevalence: A comprehensive analysis.

The Journal of steroid biochemistry and molecular biology - 1 Apr 2025

Martinelli Romina P, Petroni Candela, Martinez Josefina, Cuesta Cristina, Esteban Luis, Pacchioni Alejandra M, Arias Pablo

Abstract excerpt

There is mounting evidence that suggests vitamin D insufficiency may have a role in the emergence of type 2 diabetes. Additionally, as VDR mediates the actions of vitamin D, variants in its sequence could have implications in this disease. One of these polymorphisms, Fok1 (rs2228570), has been demonstrated to generate changes in the receptor's structure, causing a shorter protein. The purpose of this research is...

Read the complete abstract on PubMed

Topics

Receptors, Calcitriol
Humans
Diabetes Mellitus, Type 2

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Polymorphism, Single Nucleotide

Prevalence

Genetic Predisposition to Disease

Deoxyribonucleases, Type II Site-Specific

Source

Identifiers

PMID: 39914679
DOI: 10.1016/j.jsbmb.2025.106692

Genes

VDR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 23 Oct 2026.

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