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Article

Antiviral treatment causes a unique mutational signature in cancers of transplantation recipients.

Cell stem cell - 7 Oct 2021

de Kanter Jurrian K, Peci Flavia, Bertrums Eline, Rosendahl Huber Axel, van Leeuwen Anaïs, van Roosmalen Markus J, Manders Freek, Verheul Mark, Oka Rurika, Brandsma Arianne M, Bierings Marc, Belderbos Mirjam, van Boxtel Ruben

Abstract excerpt

Genetic instability is a major concern for successful application of stem cells in regenerative medicine. However, the mutational consequences of the most applied stem cell therapy in humans, hematopoietic stem cell transplantation (HSCT), remain unknown. Here we characterized the mutation burden of hematopoietic stem and progenitor cells (HSPCs) of human HSCT recipients and their donors using whole-genome...

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Identifiers

PMID: 34496298
DOI: 10.1016/j.stem.2021.07.012
PMCID: PMC8516432

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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