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Article

Characterization of clonal dynamics using duplex sequencing in donor-recipient pairs decades after hematopoietic cell transplantation.

Science translational medicine - 23 Oct 2024

Oshima Masumi Ueda, Higgins Jacob, Jenkins Isaac, Randolph Timothy, Smith Thomas, Valentine Charles, Salk Jesse, Yeung Cecilia, Beppu Lan, Campbell Judy, Carpenter Paul A, Lee Stephanie J, Flowers Mary E, Radich Jerald P, Storb Rainer

Abstract excerpt

After allogeneic hematopoietic cell transplantation (HCT), a very small number of donor stem cells reconstitute the recipient hematopoietic system, whereas the donor is left with a near-normal pool of stem cells. We hypothesized that the increased replicative stress on transplanted donor cells in the recipient could lead to the disproportionate proliferation of clonal hematopoiesis (CH) variants. We obtained...

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PMID: 39441907
DOI: 10.1126/scitranslmed.ado5108

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