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Article

Ganciclovir-induced mutations are present in a diverse spectrum of post-transplant malignancies.

Genome medicine - 31 Oct 2022

Fang Hu, Yan Helen H N, Bilardi Rebecca A, Flensburg Christoffer, Yang Haocheng, Barbour Jayne A, Siu Hoi Cheong, Turski Michelle, Chew Edward, Xu Zhen, Lam Siu T, Sharma Rakesh, Xu Mengya, Li Junshi, Ip Ho W, Cheung Carol Y M, Huen Michael S Y, Sweet-Cordero E Alejandro, Majewski Ian J, Leung Suet Y, Wong Jason W H

Abstract excerpt

BACKGROUND: Ganciclovir (GCV) is widely used in solid organ and haematopoietic stem cell transplant patients for prophylaxis and treatment of cytomegalovirus. It has long been considered a mutagen and carcinogen. However, the contribution of GCV to cancer incidence and other factors that influence its mutagenicity remains unknown. METHODS: This retrospective cohort study analysed genomics data for 121,771...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 36316687
DOI: 10.1186/s13073-022-01131-w
PMCID: PMC9620652

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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