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Article

Mutational Signature in Cancers Following Solid Organ or Allogeneic Stem Cell Transplantation.

Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc - 1 Jan 2026

Odintsov Igor, Siegmund Stephanie E, Mahadevan Navin R, Church Alanna J, Sholl Lynette M, Nowak Jonathan A

Abstract excerpt

Transplant recipients are at a heightened risk of cancer, yet the full spectrum of etiologic factors is poorly understood. In this study, we analysed the mutational patterns in a clinically diverse cohort of 41,874 cancers and identified a mutational signature highly associated with a history of solid organ or allogeneic stem cell transplantation. This signature is characterized by a high tumor mutation burden...

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Identifiers

PMID: 41135769
DOI: 10.1016/j.modpat.2025.100921
PMCID: PMC12882828

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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