Prolonged persistence of mutagenic DNA lesions in somatic cells.

doi:10.1038/s41586-024-08423-8

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Article

Prolonged persistence of mutagenic DNA lesions in somatic cells.

Nature - 1 Feb 2025

Spencer Chapman Michael, Mitchell Emily, Yoshida Kenichi, Williams Nicholas, Fabre Margarete A, Ranzoni Anna Maria, Robinson Philip S, Kregar Lori D, Wilk Matthias, Boettcher Steffen, Mahbubani Krishnaa, Saeb Parsy Kourosh, Gowers Kate H C, Janes Sam M, Ng Stanley W K, Hoare Matt, Green Anthony R, Vassiliou George S, Cvejic Ana, Manz Markus G, Laurenti Elisa, Martincorena Iñigo, Stratton Michael R, Nangalia Jyoti, Coorens Tim H H, Campbell Peter J

Abstract excerpt

DNA is subject to continual damage, leaving each cell with thousands of individual DNA lesions at any given moment1-3. The efficiency of DNA repair means that most known classes of lesion have a half-life of minutes to hours3,4, but the extent to which DNA damage can persist for longer durations remains unknown. Here, using high-resolution phylogenetic trees from 89 donors, we identified mutations arising from...

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PMID: 39814886
DOI: 10.1038/s41586-024-08423-8
PMCID: PMC11839459

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