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ApoE4 attenuates autophagy via FoxO3a repression in the brain

2 Sept 2021

Abstract excerpt

Apolipoprotein E (ApoE) plays multiple roles in lipid transport, neuronal signaling, glucose metabolism, mitochondrial function, and inflammation in the brain. It is also associated with neurodegenerative diseases, and its influence differs depending on the isoform. In particular, the ε4 allele of APOE is the highest genetic risk factor for developing late-onset Alzheimer's disease (AD). However, the mechanism by...

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PMID: 34475505
DOI: 10.1038/s41598-021-97117-6

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