Article
Apolipoprotein E and Alzheimer disease.
Neurology - 24 Jan 2006
Huang Yadong
Abstract excerpt
Apolipoprotein (apo) E, a multifunctional protein with central roles in lipid metabolism and neurobiology, has three common isoforms (apoE2, apoE3, and apoE4) with different effects on lipid homeostasis and neurobiology. Unlike apoE3, the most common isoform, apoE4, is associated with increased risk of developing Alzheimer disease (AD) and other neurodegenerative disorders. Although the mechanisms underlying...
Topics
- Age of Onset
- Aged
- Aged, 80 and over
- Alleles
- Alzheimer Disease
- Amyloid beta-Peptides
- Amyloid beta-Protein Precursor
- Animals
- Apolipoprotein E4
- Apolipoproteins E
- Astrocytes
- Brain
- Cytoskeleton
- Drug Design
- Genetic Predisposition to Disease
- Genotype
- Humans
- Lipid Metabolism