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Article

Systematic identification of regulatory variants associated with cancer risk.

Genome biology - 23 Oct 2017

Liu Song, Liu Yuwen, Zhang Qin, Wu Jiayu, Liang Junbo, Yu Shan, Wei Gong-Hong, White Kevin P, Wang Xiaoyue

Abstract excerpt

BACKGROUND: Most cancer risk-associated single nucleotide polymorphisms (SNPs) identified by genome-wide association studies (GWAS) are noncoding and it is challenging to assess their functional impacts. To systematically identify the SNPs that affect gene expression by modulating activities of distal regulatory elements, we adapt the self-transcribing active regulatory region sequencing (STARR-seq) strategy, a...

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Share to Cyclic Nucleotide Phosphodiesterases, Type 4
Share to Enhancer Elements, Genetic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 29061142
DOI: 10.1186/s13059-017-1322-z
PMCID: PMC5651703

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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