Noncoding mutations target cis-regulatory elements of the FOXA1 plexus in prostate cancer.

doi:10.1038/s41467-020-14318-9

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Article

Noncoding mutations target cis-regulatory elements of the FOXA1 plexus in prostate cancer.

Nature communications - 23 Jan 2020

Zhou Stanley, Hawley James R, Soares Fraser, Grillo Giacomo, Teng Mona, Madani Tonekaboni Seyed Ali, Hua Junjie Tony, Kron Ken J, Mazrooei Parisa, Ahmed Musaddeque, Arlidge Christopher, Yun Hwa Young, Livingstone Julie, Huang Vincent, Yamaguchi Takafumi N, Espiritu Shadrielle M G, Zhu Yanyun, Severson Tesa M, Murison Alex, Cameron Sarina, Zwart Wilbert, van der Kwast Theodorus, Pugh Trevor J, Fraser Michael, Boutros Paul C, Bristow Robert G, He Housheng Hansen, Lupien Mathieu

Abstract excerpt

Prostate cancer is the second most commonly diagnosed malignancy among men worldwide. Recurrently mutated in primary and metastatic prostate tumors, FOXA1 encodes a pioneer transcription factor involved in disease onset and progression through both androgen receptor-dependent and androgen receptor-independent mechanisms. Despite its oncogenic properties however, the regulation of FOXA1 expression remains unknown....

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PMID: 31974375
DOI: 10.1038/s41467-020-14318-9
PMCID: PMC6978390

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