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Deletion of mFICD AMPylase alters cytokine secretion and affects visual short-term learning in vivo

19 Aug 2021

Abstract excerpt

Fic domain-containing AMP transferases (fic AMPylases) are conserved enzymes that catalyze the covalent transfer of AMP to proteins. This posttranslational modification regulates the function of several proteins, including the ER-resident chaperone Grp78/BiP. Here we introduce a mouse FICD (mFICD) AMPylase knockout mouse model to study fic AMPylase function in vertebrates. We find that mFICD deficiency is well...

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PMID: 34419450
DOI: 10.1016/j.jbc.2021.100991

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