Article

Neuroinflammation underlies the development of social stress induced cognitive deficit in sickle cell disease

2024-01-25

Abstract excerpt

Cognitive deficit is a debilitating complication of SCD with multifactorial pathobiology. Here we show that neuroinflammation and dysregulation in lipidomics and transcriptomics profiles are major underlying mechanisms of social stress-induced cognitive deficit in SCD. Townes sickle cell (SS) mice and controls (AA) were exposed to social stress using the repeat social defeat (RSD) paradigm concurrently with or wit...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: d93de9da-5960-5345-bf27-f35df7296e79
DOI: 10.1101/2024.01.24.577074

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Neuroinflammation underlies the development of social stress induced cognitive deficit in sickle cell diseaseDOI 10.1101/2024.01.24.577074Read

Age and neuroinflammation are important components of the mechanism of cognitive and neurobehavioral deficits in sickle cell diseaseSemantic proximity Read

Neuropathological hallmarks during the chronic phase of ischemic stroke in mice and humansSemantic proximity Read

Frataxin deficiency in the astrocytes drives neurocognitive impairment in sickle cell disease miceSemantic proximity Read

Ketogenic diet alters microglial morphology and changes the hippocampal lipidomic profile distinctively in stress susceptible <i>versus</i> resistant male mice upon repeated social defeatSemantic proximity Read

From Bone Marrow Mutation to Cognitive Deficit: A Strategy for Personalised Correction of CHIP-Associated Neuroinflammation in Cardiac SurgerySemantic proximity Read

Cognitive impairment and progressive neuroinflammation in mucopolysaccharidosis IIIA mice expressing the R245H Sgsh variantSemantic proximity Read

Cognitive and behavior deficits in sickle cell mice are associated with profound neuropathologic changes in hippocampus and cerebellum.Semantic proximity Read

Genetic Control of Myelin Plasticity after Chronic Psychosocial StressSemantic proximity Read

Intergenerational Perioperative Neurocognitive DisorderSemantic proximity Read

Effects of fingolimod administration in a genetic model of cognitive deficits.Semantic proximity Read

Exercise Attenuates Obesity-Related Cognitive and Sleep-Circadian Dysfunctions by Attenuating Neuroinflammation via JAK/STAT in Sex and Age Specific MannerSemantic proximity Read

Epigenetic impacts of stress priming of the neuroinflammatory response to sarin surrogate in mice: a model of Gulf War illnessSemantic proximity Read