Article
Megf10 Is a Receptor for C1Q That Mediates Clearance of Apoptotic Cells by Astrocytes.
The Journal of neuroscience : the official journal of the Society for Neuroscience - 11 May 2016
Iram Tal, Ramirez-Ortiz Zaida, Byrne Michael H, Coleman Uwanda A, Kingery Nathan D, Means Terry K, Frenkel Dan, El Khoury Joseph
Abstract excerpt
UNLABELLED: Multiple EGF-like domains 10 (Megf10) is a class F scavenger receptor (SR-F3) expressed on astrocytes and myosatellite cells, and recessive mutations in humans result in early-onset myopathy, areflexia, respiratory distress, and dysphagia (EMARDD). Here we report that Megf10-deficient mice have increased apoptotic cells in the developing cerebellum and have impaired phagocytosis of apoptotic cells by...
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